Figure 1: Kaplan-Meier curve and disease-free survival (5-year disease-free survival rate for patients with R0 resection=73%).
|
Patients (N=162) |
Age, mean (range) |
43 (34 - 74) |
BMI, mean (range) |
29 (19 - 48) |
Gender (male) |
99 (60%) |
Smoking |
81 (50%) |
Diabetes |
37 (22%) |
COPD |
10 (6%) |
Preoperative Imaging |
|
MRI |
59 (36%) |
CT |
103 (63%) |
Neoadjuvant Therapy |
|
Radiation |
139 (83%) |
Chemotherapy |
138 (82%) |
Adjuvant Therapy |
|
Radiation |
10 (6%) |
Chemotherapy |
44 (27%) |
Table 1: Patient Demographics and Characteristics
BMI: Body Mass Index, COPD: Chronic Obstructive Pulmonary Disease, CT: Computed Tomography, MRI: Magnetic Resonance Imaging.
|
Patients (N=162) |
Operative Approach |
|
Open |
127 (79%) |
Laparoscopic trial |
35(21%) |
Conversion |
7/35(20%) |
Overall EBL, mean (range), mL |
300 (100 – 2100) |
Open EBL, mean (range), mL |
550 (200 – 2100) |
Lap EBL, mean (range), mL |
200 (100 – 500) |
Mean Overall Op time min |
280 (145 – 347) |
Mean Open Op time min |
300 (150 – 320) |
Mean Lap Op time min |
225 (160 – 320) |
Table 2: Operative Characteristics
EBL - Estimated Blood Loss, Op time - Operative time
|
Patients (N=162) |
Overall Complications |
41 (25%) |
Perineal wound complications |
14 (9%) |
SSI |
8 (5%) |
UTI |
8 (5%) |
Chest infection |
3 (2%) |
PE |
1 (1%) |
DVT |
4 (2.5%) |
Hospital Death |
1 (0.6%) |
LOS, mean (range), days |
9 (3 – 38) |
Follow-up, mean (range), months |
33.8 (3- 117) |
Table 3: Post-Operative Surgical Complications
UTI - Urinary Tract Infection, SSI-surgical site infection, DVT - Deep Vein Thrombosis, PE - Pulmonary Embolism, LOS - Length of Stay
|
Patients (N=162) |
Pathologic Tumor Stage |
|
Stage I |
15 (10%) |
Stage IIA |
30 (19%) |
Stage IIB |
20 (12.5%) |
Stage IIC |
20 (12.5%) |
Stage IIIA |
19 (11.5%) |
Stage IIIB |
21 (13%) |
Stage IIIC |
16 (10%) |
Stage IV |
6 (3.7%) |
No Residual Malignancy |
15 (10%) |
(after neoadjuvant therapy) |
|
Tumor size, mean (cm) |
3.2 (0.3 - 10) |
Tumor Margins |
|
CRM Positive (R1) |
14/162 (8.5%) |
Laparoscopy CRM Positive |
3/28 (10.6%) |
Open CRM Positive |
11/134 (8.2%) |
CRM Distance, mean (mm) |
7 (3.0 - 25) |
Distal Margin, mean (cm) |
4.8 (0.9 -24) |
Resection Classification |
|
R0 |
136 (84%) |
R1 |
14 (8.5%) |
R2 |
12 (7.5%) |
Recurrence |
|
Local |
4 (2.5%) |
Distal |
12 (7.5%) |
Table 4: Oncological Findings for Rectal Adenocarcinoma
CRM: Circumferential Resection Margin
Figure 1: Kaplan-Meier curve and disease-free survival (5-year disease-free survival rate for patients with R0 resection=73%).
Figure 2: Kaplan-Meier Curve, Overall survival (5-year -Overall-Survival rate 84%). The 5-year -Overall-Survival rate 73%.
Tables at a glance
Figures at a glance