Figure 1 Kaplan-Meier survival estimates by BMI category

Figure 2 Kaplan-Meier Survival Estimate by Race/Ethnicity (N = 1323)

Variable

 

Percentage

Non-underweight*

Underweight*

P-Value

BMI

Under weight

4.02

 

 

 

 

Normal

33.04

 

 

 

 

Overweight

29.68

 

 

 

 

Obese I

18.20

 

 

 

 

Obese II

8.99

 

 

 

 

Obese III

6.07

 

 

 

Age at dx

Age at dx <= 50

25.66

25.29

34.55

0.1546

 

Age at dx > 50

74.34

74.71

65.45

 

Race/Ethnicity

NH white

83.67

83.62

84.91

0.6570

 

NH black

8.77

8.90

5.66

 

 

Hispanic

7.56

7.48

9.43

 

Social economic status**

SEG 1

13.60

13.33

20.00

0.2308

 

SEG 2

33.48

33.59

30.91

 

 

SEG 3

30.34

30.77

20.00

 

 

SEG 4

20.83

20.64

25.45

 

 

Unknown

1.75

1.68

3.64

 

Married

Single

45.32

45.16

49.09

0.8385

 

Married

51.17

51.33

47.27

 

 

Unknown

3.51

3.50

3.64

 

Insurance

Not insured

3.00 

2.89

5.45

0.6711

 

Medicaid

8.11

8.00

10.91

 

 

Medicare

32.68

32.75

30.91

 

 

Private insurance

53.80 

54.00

49.09

 

 

Unknown

2.41

2.36

3.64

 

Total comorbidity

 

0.65 (1.29)

0.65 (1.31)

0.49 (0.96)

0.2330

Table1 Patient characteristics and relation with underweight (N = 1,368)

* column % or mean (std. dev.) ** SEG 1 = “> 20% living in poverty”, SEG 2 = “Between 10% and <20% of population living in poverty”, SEG 3 = “Between 5% and <10% of population living in poverty”, SEG 4 = “< 5% of population living in poverty”

Variable

 

Percentage

Non-underweight*

Underweight*

P-Value

ER

-

18.64

18.20

29.09

0.1151

 

+

76.54

77.00

65.45

 

 

Unknown

4.82

4.80

5.45

 

PR

-

32.75

32.29

43.64

0.2006

 

+

61.99

62.45

50.91

 

 

Unknown

5.26

5.26

5.45

 

HER2

-

42.91

42.80

45.45

0.6140

 

+

11.40

11.58

7.27

 

 

Unknown

45.69

45.62

47.27

 

Triple Negative

No

79.61

79.97

70.91

0.1168

 

Yes

6.29

6.32

5.45

 

 

Unknown

14.11

13.71

23.64

 

Breast surgery

No surgery

2.19

2.13

3.64

0.0772

 

Mastectomy

40.13

39.98

43.64

 

 

Other surgery

49.20

49.73

36.36

 

 

Unknown

8.48

8.15

16.36

 

Hormone

No

74.34

74.26

76.36

0.5362

 

Yes

23.54

23.53

23.64

 

 

Unknown

2.12

2.21

0.00

 

Radiation

No

66.59

66.49

69.09

0.2464

 

Yes

32.97

33.13

29.09

 

 

Unknown

0.44

0.38

1.82

 

Chemo

No

54.02

53.92

56.36

0.8750

 

Yes

41.30

41.43

38.18

 

 

Unknown

4.68

4.65

5.45

 

Stage

Localized

56.51

56.97

45.45

0.0007

 

Regional

33.77

33.89

30.91

 

 

Distant

5.77

5.26

18.18

 

 

Unknown/unstaged

3.95

3.88

5.45

 

Grade

Well-differentiated

19.08

19.27

14.55

0.1262

 

Moderately-differentiated

37.87

38.23

29.09

 

 

Poorly- or un-differentiated

43.06

42.50

56.36

 

Histology

Ductal

83.77

83.93

80.00

0.4992

 

Lobular

10.67

10.66

10.91

 

 

Other

5.56

5.41

9.09

 

Tumor Size (mm)

 

24.40 (22.62)

24.24 (22.45)

28.05 (26.35)

0.2210

Number of positive nodes examined

 

1.29 (2.98)

1.27 (2.95)

1.95 (3.63)

0.1775

Total number of nodes examined

 

6.88 (7.90)

6.97 (7.94)

4.65 (6.48)

0.0329

Table2 Tumor characteristics and treatment, and relation with underweight (N = 1,368)

* column % or mean (std. dev.)

Variable

 

Hazard Ratio

 

95% CI

P-Value

BMI (vs. Normal weight)

Underweight

2.612

1.200

5.685

0.0156

 

Overweight

1.130

0.638

2.004

0.6752

 

Obese

1.710

0.965

3.030

0.0660

Age at dx (vs. <= 50)

Age at dx > 50

0.713

0.418

1.217

0.2152

Race/Ethnicity(vs. NH white)

NH black

1.272

0.598

2.704

0.5317

 

Hispanic

0.678

0.260

1.767

0.4260

Social economic status (vs. SEG 4)*

SEG 1

0.574

0.258

1.280

0.1753

 

SEG 2

0.592

0.310

1.131

0.1124

 

SEG 3

0.902

0.497

1.637

0.7346

 

Unknown

0.370

0.062

2.221

0.2770

Married (vs. Married)

Single

1.071

0.670

1.711

0.7749

 

Unknown

0.628

0.139

2.843

0.5462

Insurance (vs. Private insurance)

Not insured

2.246

0.814

6.198

0.1181

 

Medicaid

1.766

0.930

3.354

0.0821

 

Medicare

2.422

1.394

4.208

0.0017

Total comorbidity

 

0.914

0.791

1.056

0.2206

Triple Negative (vs. Non-Triple Negative)

Triple Negative

8.514

3.940

18.400

<.0001

 

Unknown

4.501

2.663

7.607

<.0001

Breast surgery (vs. No surgery)

Mastectomy

2.848

0.899

9.016

0.0751

 

Other surgery

3.398

0.997

11.582

0.0505

 

Unknown

 4.768

1.588

14.316

0.0054

Hormone (vs. No-Hormone)

Hormone

1.205

0.603

2.410

0.5976

 

Unknown

1.572

0.135

18.335

0.7181

Radiation (vs. No-Radiation)

Radiation

1.407

0.830

2.384

0.2043

 

Unknown

2.895

0.461

18.175

0.2567

Chemo(vs. No-Chemo)

Chemo

1.117

0.699

1.784

0.6446

 

Unknown

0.999

0.233

4.283

0.9994

Stage (vs. Localized)

Regional

1.883

0.931

3.809

0.0783

 

Distant

10.522

4.950

22.367

<.0001

 

Unknown /unstaged 

4.455

1.923

10.322

0.0005

Grade (vs. Well-differentiated)

Moderately-differentiated

3.318

0.761

14.470

0.1104

 

Poorly- or un-differentiated

4.109

0.955

17.682

0.0577

Histology(vs. Ductal)

Lobular

1.299

0.659

2.561

0.4496

 

Other

0.621

0.290

1.329

0.2201

Tumor Size (mm)

 

1.015

1.008

1.022

<.0001

Number of positive nodes examined

 

1.160

1.087

1.238

<.0001

Total number of nodes examined

 

0.957

0.919

0.995

0.0281

Underweight x NH black

 

0.425

 

 

0.3993

Underweight x Hispanic

 

0.560

 

 

0.6320

Table3 multivariate survival analysis of time to breast cancer death (N = 1,292)

* SEG 1 = “> 20% living in poverty”, SEG 2 = “Between 10% and <20% of population living in poverty”, SEG 3 = “Between 5% and <10% of population living in poverty”, SEG 4 = “< 5% of population living in poverty”