Figure 1 Flow chart of biopsy results for each type of smear referral

Smear Result	Number of women	%
Negative for Squamous Lesion	166	76%
Low grade/ Atypical squamous cells of undetermined significance	38	17%
High grade/Atypical squamous cells favouring high grade	2	1%
Reactive	1	<1%
Not done	12	5%

Table 1 – Smear result at referral

Histology result	Number of women	%
No biopsy taken, normal colposcopy	122	74%
Normal	22	13%
CIN 1	17	10%
CIN 2	2	1.2%
CIN 3	2	1.2%
Cervical cancer	1	0.6%

Table 2 – Histology results in women with normal referral smear

Examination Finding	n
Normal	43	20%
Ectropion	80	37%
Polyp	9	4%
HPV/low grade changes	67	31%
High grade	15	7%
Malignancy	1	0.50%
Vaginal tear	1	0.50%
Cervical fibroid	1	0.50%
Inflammation	12	5%
Endocervical button post lletz	6	3%
Declined	1	0.50%

Table 3 – Colposcopic examination findings - all women referred

*Some patients had more than one examination finding so percentages do not add to 100.

Histology result	n	Proportion of women that had biopsy taken	Proportion of all women referred with PCB
No biopsy taken	109		50%
Normal	36	33%	15%
Inflammation	24	22%	11%
HPV/CIN1	29	26%	13%
CIN2	6	5%	3%
CIN3	5	5%	2%
Cancer - SCC	1	<1%	<1%
Fibroid	1	<1%	<1%
Insuffficient	3	3%	1.4%
Benign polyp	5	5%	2%

Table 4 – Histology results for women that had colposcopically guided biopsies

Table 5 – Treatments offered after biopsy

†PRINCess: The Prediction of Regression in CIN2 – a multicentre trial.