Figure 1 Flow chart of biopsy results for each type of smear referral

Smear Result

Number of women

%

Negative for Squamous Lesion

166

76%

Low grade/ Atypical squamous cells of undetermined significance

38

17%

High grade/Atypical squamous cells favouring high grade

2

1%

Reactive

1

<1%

Not done

12

5%

Table 1 – Smear result at referral

Histology result

Number of women

%

No biopsy taken, normal colposcopy

122

74%

Normal

22

13%

CIN 1

17

10%

CIN 2

2

1.2%

CIN 3

2

1.2%

Cervical cancer

1

0.6%

Table 2 – Histology results in women with normal referral smear

Examination Finding

n

Normal

43

20%

Ectropion

80

37%

Polyp

9

4%

HPV/low grade changes

67

31%

High grade

15

7%

Malignancy

1

0.50%

Vaginal tear

1

0.50%

Cervical fibroid

1

0.50%

Inflammation

12

5%

Endocervical button post lletz

6

3%

Declined

1

0.50%

Table 3 – Colposcopic examination findings - all women referred

*Some patients had more than one examination finding so percentages do not add to 100.

Histology result

n

Proportion of women that had biopsy taken

Proportion of all women referred with PCB

No biopsy taken

109

 

50%

Normal

36

33%

15%

Inflammation

24

22%

11%

HPV/CIN1

29

26%

13%

CIN2

6

5%

3%

CIN3

5

5%

2%

Cancer - SCC

1

<1%

<1%

Fibroid

1

<1%

<1%

Insuffficient

3

3%

1.4%

Benign polyp

5

5%

2%

Table 4 – Histology results for women that had colposcopically guided biopsies

Treatment

n

Diathermy

21

19%

LLETZ

14

13%

Cone biopsy

0

0

Follow up colposcopy

18

16%

Ultrasound gynae

3

3%

Silver nitrate

11

10%

Radical hysterectomy

1

<1%

Antibiotics

1

<1%

Hysteroscopy + D&C

1

<1%

PRINCESS† study

1

<1%

No treatment after biopsy

38

35%

Table 5 – Treatments offered after biopsy

†PRINCess: The Prediction of Regression in CIN2 – a multicentre trial.