Figure 1 Box plot of sFlt-1, PlGF, and their ratio for patients who had IUGR-related delivery against isolated preeclampsia.

Figure 2 Roc curve analysis for sFlt-1, PlGF, and their ratio as a diagnostic value for predicting IUGR at delivery.

Figure 3 Box plot of the uterine artery PI for patients who eventually develop IUGR against those without.

	IUGR related	median	min.	max.	n.	r	P
sFlt-1	no	4217	22.97	69761	441	0.29	0.69
	yes	8239	85	45017	136
PlGF	no	177.5	7	3604	441	0.46	0.19
	yes	56.11	3	528	136
Ratio	no	24.92	0.45	723.4	441	0.45	0.81
	yes	154.4	2.55	1551.3	136

Table 1. The results of the Wilcoxon-Mann-Whitney-U test for the angiogenesis factors and IUGR at delivery (min: minimum, max: maximum, n: number of patients, r: effect size, P: Mann-Whitney P value)

		sFlt-1	PlGF	Ratio
Uterine artery PI	ρ p	0.14 <10-3	-0.43 <10-6	0.33 <10-6
Diabetes	ρ p	-0.07 0.06	-0.04 0.25	-0.03 0.47
Gestational age at delivery	ρ p	-0.32 <10-6	0.3 <10-6	-0.39 <10-6
5 minutes APGAR	ρ p	-0.15 <10-3	0.23 <10-6	-0.22 <10-6
Birth weight	ρ p	-0.37 <10-6	0.41 <10-6	-0.49 <10-6

Table 2. The results of Spearman's correlation between the angiogenesis factors and Doppler results, diabetes and other delivery variables (ρ = Spearman's correlation Rho, p = value for statistical significance)

Uterine artery PI	median	Range	1. quartile	3. quartile
Normal	0.77	0.37-2.99	0.6	1.07
IUGR	1.23	0.33-3.33	0.94	1.66

Table 3. Comparison of the uterine artery PI values in patients who develop IUGR and normal patients