Figure 1 Box plot of sFlt-1, PlGF, and their ratio for patients who had IUGR-related delivery against isolated preeclampsia.

Figure 2 Roc curve analysis for sFlt-1, PlGF, and their ratio as a diagnostic value for predicting IUGR at delivery.

Figure 3 Box plot of the uterine artery PI for patients who eventually develop IUGR against those without.

 

IUGR related

median

min.

max.

n.

r

P

sFlt-1

no

4217

22.97

69761

441

0.29

0.69

yes

8239

85

45017

136

PlGF

no

177.5

7

3604

441

0.46

0.19

yes

56.11

3

528

136

Ratio

no

24.92

0.45

723.4

441

0.45

0.81

yes

154.4

2.55

1551.3

136

Table 1. The results of the Wilcoxon-Mann-Whitney-U test for the angiogenesis factors and IUGR at delivery (min: minimum, max: maximum, n: number of patients, r: effect size, P: Mann-Whitney P value)

 

sFlt-1

PlGF

Ratio

Uterine artery PI

ρ

p

0.14

<10-3

-0.43

<10-6

0.33

<10-6

Diabetes

ρ

p

-0.07

0.06

-0.04

0.25

-0.03

0.47

Gestational age at delivery

ρ

p

-0.32

<10-6

0.3

<10-6

-0.39

<10-6

5 minutes APGAR

ρ

p

-0.15

<10-3

0.23

<10-6

-0.22

<10-6

Birth weight

ρ

p

-0.37

<10-6

0.41

<10-6

-0.49

<10-6

Table 2. The results of Spearman's correlation between the angiogenesis factors and Doppler results, diabetes and other delivery variables (ρ = Spearman's correlation Rho, p = value for statistical significance)

Uterine artery PI

median

Range

1. quartile

3. quartile

Normal

0.77

0.37-2.99

0.6

1.07

IUGR

1.23

0.33-3.33

0.94

1.66

Table 3. Comparison of the uterine artery PI values in patients who develop IUGR and normal patients