VARIABLES	N = 109
AGE(years)	31.2 ± 6.2
NATIONALITY Caucasian Non caucasian	96 (88.1%) 13 (11.9%)
PREVIOUS LIVER DISEASE Yes No	57 (52.3%) 52 (47.7%)
PATTERN OF LIVER DAMAGE Cholestatic Viral Metabolic Others	32 (29,3%) 22 (20,4%) 46 (42.2%) 9 (8.3%)
ALT(IU/L) II Trimester III Trimester	86.7 ± 185.2 137.8 ±174.2
PROM	11 (10.1%)
DELIVERY Caesarean section Vaginal	74 (67.9%) 35 (32.1%)
TIMING OF DELIVERY (weeks)	37.4 ± 3.5
NEWBORN PARAMETERS Apgar score < 9 Weight (gr)	13 (11.9%) 3,124 ± 569
MULTIPLE ABORTION	8 (7.3%)
DM before pregnancy	10 (9.1%)
GDM	19 (17.4%)

Table 1: Clinical and biochemical features of pregnant presenting with liver damage

PROM: pre-labour rupture of membranes. DM: diabetes mellitus. GDM: Gestational diabetes mellitus

VARIABLES

CHOLESTATIC
(32)

VIRAL
(22)

METABOLIC
(46)

OTHERS
(9)

P-value

AGE(years)

31.9 ± 5.4

26.7 ± 6.1

31.4 ± 6.8

31.9 ± 5.8

0.60

NATIONALITY
Caucasian Non caucasian

27 (84.4%)
5 (15.6%)

16 (72.7%)
6 (27.3%)

40 (87.0%)
6 (13.0%)

12 (100%)
0

0.89

COMORBIDITY
Hypertension Diabetes mellitus

1 (3.1%)
0

0
1 (4.5%)

0
8 (17.4%)

0
1 (11.1%)

0.58
0.02

PREVIOUS LIVER DISEASE
Yes No

1 (3.1%)
31 (96.9%)

19 (86.4%)
3 (13.6%)

37 (80.4%)
9 (19.6%)

0
9 (100%)

<0.001

SYMPTOMS
Pruritus Nausea

25 (78.1%)
0

0
2 (9.1%)

0
1 (2.2%)

0
0

< 0.001
0.21

ALT (UI/L)
II Trimester III Trimester

198.9 ± 349
271.7 ± 220.5

24,6 ±13.9
21.2 ± 8.2

45.9 ± 35.6
83.5 ± 96.2

120.7 ± 90.8
96.3 ± 6.6

0.06
< 0.001

DELIVERY MODALITY PROM
Caesarean section
Vaginal

6 (18.7%)
22 (68.7%)
10 (31.3%)

1 (4.6%)
16 (70.0%)
6 30.0%)

3 (6.5%)
29 (56.5%)
17(32.6%)

1 (1.1%)
7 (77.8%)
2 (22.2%)

0.2
0.8

TIMING OF DELIVERY
(weeks)

37.6 ± 3.0

38.3±1.3

37.4±3.7

34.9 ± 6.6

0.17

NEWBORN PARAMETERS
Apgarscore< 8 Weight (gr)

4 (12.5%)
3,055 ± 465

1 (4.6%)
3,235± 423

4 (8.7%)
3,206 ± 618

4 (44.4%)
2,747± 888

0.01
0.2

MULTIPLE ABORTION

1 (3.1%)

1 (4.6%)

5 (19.9%)

1 (11.1%)

0.5

DM before pregnancy

0

1 (4.6%)

8 (17.4%)

1 (11.1%)

0.06

GDM

8 (25%)

3 (13.6%)

4 (8.7%)

4 (44.4%)

0.036

Table 2: Comparison of clinical features of pregnant within different patterns of liver damage

PROM: prelabor rupture of membranes. DM: diabetes mellitus. GDM: Gestational diabetes mellitus

VARIABLES	ABCB11-CC (N=12)	ABCB11 -TT (N=2)	ABCB11-TC (N=5)	p
PRURITUS	12 (100%)	1 (50.0%)	3 (60.0%)	0.04
ALT (UI/l) (mean ± SD)	351.2 ± 258.4	351.4 ± 198.8	393.28 ± 248.2	0.7
PREGNANCY OUTCOME IUFD IUGR	1 (8.3%) 1 (8.3%)	- -	- -	0.7 0.7
PROM	1 (8.3%)	-	3 (60.0%)	0.04
APGARE SCORE < 8	4 (33.3%)	-	1(20.0%)	0.6

Figures at a glance