N Total
= 182

Mean ± Standard deviation
or median (Quartile 1− Quartile 3)
or n (% of patients)

Age (years)
      mean ± SD
      median (Q1−Q3)

178

32 ± 5.0
32 (28−36)

Age ≥ 35 years, n(%)

55 (30.9)

Parity
      0
      1
     >1

178

34 (19.1)
81 (45.5)
63 (35.4)

BMI before the beginning of
pregnancy (kg/m2)
      mean ± SD
      median (Q1−Q3)

176

25.3 ± 6.6
23.6 (20.9−28.2)

BMI >25 (kg/m2)

71 (40.3)

Smoking, n (%)

178

22 (12.4)

Diabetes, n (%)

180

6 (3.3)

Kidney disease, n (%)

180

4 (2.2)

Hypertension, n (%)

180

17 (9.4)

Lupus, n (%)

180

12 (6.6)

Antiphospholipid Syndrome, n (%)

179

4 (2.2)

Personal history of VTE, n (%)

181

35 (19.2)

Personal history of PMCs, n (%)

180

119 (65.4)

Familial history of cardiovascular disease or VTE, n (%)

180

38 (21.1)

Gestational age at sampling
Number of patients

18 GW
n= 175

22 GW
n= 174

26 GW
n= 174

30 GW
n= 170

34 GW
n= 157

Serum 25(OH)D (ng/mL) 
mean ± SD
median (Q1−Q3)

18.4 ± 8.6
17.3 (12.4−24.4)

19.1 ± 8.3
18.2 (12.7−24.3)

20.2 ± 8.5
18.0 (13.5−25.7)

22.4 ± 9.2
22.2 (14.7−28.3)

22.2 ± 8.3
21.6 (15.0−27.8)

25(OH)D categories n (%) 
 ≤20 ng/mL
21−29 ng/mL
≥30 ng/mL

104 (59.4)
53 (30.3)
18 (10.3)

104 (59.8)
52 (29.9)
18 (10.3)

94 (54.0)
45 (25.9)
23 (13.2)

73 (42.9)
56 (32.9)
30 (17.6)

67 (54.0)
59 (25.9)
31 (13.2)

Gestational age at sampling

18 GW
25(OH)D (ng/mL)

P value

34 GW
25(OH)D (ng/mL)

P value

≤20
N= 104

>20
N= 71

≤20
N= 67

>20
N= 90

Age (years)
< 35
≥ 35

66 (64.1)
37 (35.9)

52 (76.5)
16 (23.5)

0.09

44 (67.7)
21 (32.3)

62 (71.3)
25 (28.7)

0.64

BMI (Kg/m2)
 <25
≥25

61 (59.8)
41 (40.2)

40 (58.8)
28 (41.2)

0.90

38 (57.6)
28 (42.4)

55 (64,0)
31 (36.0)

0.42

Parity a
0
≥ 1

19 (18.5)
84 (81.6)

14 (20.3)
55 (79.7)

0.76

10 (15.2)
56 (84.9)

20 (23.0)
67 (77.0)

0.23

Smoking b
No
Yes

93 (90.3)
10 (9.7)

58 (84.1)
11 (15.9)

0.22

59 (89.4)
7 (10.6)

76 (87.4)
11 (12.6)

0.70

Personal history of PMCs
No
Yes

26 (31.1)
78 (75.7)

32 (46.4)
37 (53.6)

0.004

21 (31.3)
46 (68.7)

32 (36.4)
56 (63.6)

0.51