Biography

Dr. Sarkar earned his B.S (Hons.) in Chemistry from Presidency College, Calcutta and M.S in chemistry from IIT, Kharagpur, India. This was followed by Ph.D. research from Gates Laboratory in anticancer drug design and the mechanisms of drug action and metabolism at the University of Missouri. After receiving his PhD he joined MIT as postdoctoral associate, where he now spends most of his time in the Wishnok/Tannenbaum mass spectrometry lab. Dr. Sarkar is working in the areas of small molecule medicinal chemistry, reactive oxygen species, inflammation, small molecule biomarker exploration and drug metabolism pharmacokinetics answering fundamental questions toward biomedical applications to the prevention and cure of human diseases. Currently, in collaboration with biotech companies and a number of academic labs, Dr. Sarkar is primarily involved in the mass spectrometry based drug metabolism pharmacokinetics (DMPK) and pharmaco-metabolomics study of human liver and lung on a chip to predict safety, efficacy and toxicity of a series of drugs. He is also involved in metabolites identification of drugs, metabolomics, lipidomics profiling, and analysis of important metabolic pathways of human liver, and lung on a chip, which may help to better understand the molecular mechanism of drug toxicity and idiosyncratic risks in humans, and to further enhance innovation in new drug concept generation in the areas of inflammation, cancer and diabetes. In addition, he worked in the area of chemical biology to discover hydrolases as a potential biomarkers of various inflammatory diseases. MEMBERSHIPS: • American Chemical Society • Division of Chemical Toxicology-ACS • American Association for the Advancement of Science • International Society for the study of Xenobiotics